SN6

Accelrys Notebook	Information and documentation system for ALL the different labs
Accelrys Notebook for Synthesis	A flexible, enterprise Electronic Laboratory Notebook (ELN) that accelerates the design and execution of synthesis experiments by offering proven chemical representation, molecule/reaction searching, and compound registration capabilities with integrated material and property look-up. Symyx Notebook for Synthesis improves operational efficiencies and lowers costs by enabling synthetic and medicinal chemists to collaborate effectively with analytical chemists and biologists using a single notebook enterprise-wide in regulated and non-regulated environments. Symyx Notebook offers capabilities for handling text, data, and forms required to plan, record, analyze, and report synthesis plans—including capturing reaction transformation details and handling single- and multi-step, linear and convergent reaction schemes. Advanced security and workflow tools make Symyx Notebook ideal for third-party and outsourced R&D integration. Supporting synthetic chemistry workflows Quickly develop new synthetic methodologies and workflows Store reactions with all reaction transformation and mapping information Search for specific transformations over in-house Notebook reactions and up to 6 million commercially available reactions and methodologies provided by Symyx Accelerate stoichiometry calculations with easy look-ups of key properties like molecular formula, molecular weight, density, purity, etc. in Symyx ACD Use the Symyx Registration service to register purchased or synthesized compounds Learn from other researchers’ experiments and reuse information	New publications Enterprise ELN Strategies: The Future for Notebooks Trevor Heritage, Bioscience Technology, May 2009 Electronic Laboratory Notebooks Scientific Computing, Spring 2009 Includes What You Should Know Before Selecting an ELN by Michael Elliott, Atrium Research
Accelrys Notebook for Biology	A flexible, enterprise Electronic Laboratory Notebook (ELN) that streamlines the capture of biological information and processes, and improves collaboration with colleagues and contract research organizations. Symyx Notebook for Biology improves operational efficiencies and lowers costs by enabling biologists to plan, execute, and record experiments using a single notebook enterprise–wide, from discovery through manufacturing in regulated and non-regulated environments. Advanced security and workflow tools make Symyx Notebook ideal for third-party and outsourced R&D integration. Symyx Notebook supports a wide range of biology workflows including in vivo and in vitro experimentation for biologics, target identification and validation, assay development, screening, drug metabolism/pharmacokinetics (DMPK), toxicology, and bioanalytical experimentation. Supporting biology workflows Quickly develop new experimental processes and workflows Learn from other researchers’ experiments and reuse information Collaborate more effectively with colleagues and contract research organizations Work efficiently in regulated and non–regulated environments Search across all text; annotate chromatograms and spectra—and fully search annotations Capture and process data from many sources Reduce data transcription and omission errors by acquiring data directly from laboratory instruments (balances, LIMS, CDS, SDMS, etc.) Integrate Microsoft Excel spreadsheets into experiment write-ups Store easily accessible domain–relevant data, e.g., sequence annotations, LD50 curves, body weight changes, animal/plate requests, spreadsheets Record cell lines, proteins, buffers, in easily configurable tables with integrated calculations and look-up Hyperlink to referenced experiments for easy tracking of procedures and tests performed over multiple experiments Integrate with spreadsheet, statistical analysis, PK/PD modeling, visualization, and scientific data management software Capture changes and signatures in comprehensive audit trails Reduce time spent reviewing and routing documents for approval Save time, reduce mistakes, ease the compliance burden	ELN articles and resources A single notebook for the enterprise Trevor Heritage, Scientific Computing World, Feb/Mar 2009. Operational agility and productivity with an enterprise Notebook Bio-IT World Special Advertising Section, Jan/Feb 2009 Biologists Put Their Pencils Down Interview with John McCarthy, Instrument Business Outlook, Nov 15, 2008 Laboratory Informatics Guide 2009 Scientific Computing World, January 2009 Electronic Laboratory Notebooks Enter Mainstream Informatics Michael H. Elliott, Scientific Computing, Fall 2008
Accelrys Notebook for Analytical	A flexible, enterprise Electronic Laboratory Notebook (ELN) that streamlines the capture of analytical chemistry information and processes, and improves collaboration with colleagues and contract research organizations. Symyx Notebook for Analytical Chemistry improves operational efficiencies and lowers costs by enabling scientists in many disciplines including analytical chemistry to plan, execute, and record experiments using a single notebook enterprise-wide, from discovery through manufacturing. Supporting analytical workflows Quickly develop new methods Learn from other researchers’ experiments and reuse information Collaborate more effectively with colleagues and contract research organizations Work efficiently in regulated and non–regulated environments Search across all text; annotate chromatograms and spectra–and fully search annotations Capture and process data from many sources Reduce data transcription and omission errors by acquiring data directly from laboratory instruments (e.g., balances) Capture Microsoft Excel spreadsheets into experiment write–ups Utilize flexible tables with integrated calculations and information look–up Hyperlink to referenced experiments for easy tracking of procedures and tests performed over multiple experiments Capture spreadsheet, statistical analysis, kinetic modeling, visualization, and scientific data management information Capture changes and signatures in comprehensive audit trails Reduce time spent reviewing and routing documents for approval Save time, reduce mistakes, ease the compliance burden
Accelrys Discovery Notebook	An Electronic Laboratory Notebook (ELN) designed for pharmaceutical discovery chemists to draw on prior experience, develop new methods, access relevant information, and integrate with critical systems. Symyx Discovery Notebook enables chemists in small molecule pharmaceutical discovery to plan, record, and analyze research, experiments, and procedures more efficiently and effectively than with traditional paper lab notebooks, typically saving 5–10% of their time when performing a series of related reactions. Prepare: Access information from multiple sources and plan reactions Search for experiments providing similar products or reactions to utilize the knowledge and expertise of colleagues. Access and incorporate the structures and data from corporate and external sources (e.g., reagent inventory, registry). Compute quantities Identify reactants and products Calculate stoichiometry Scale reactions Label products for analysis Attach analyses Document: Simplify observation entry and generate reports for meetings or archives Utilize common and customized phrases and materials to improve the speed and accuracy of entry Incorporate keywords, defined properties, and safety information to classify and find relevant experiments Associate analytical data appropriately to procedures, products, and reactions Collect experiments into a single report to present designs and discuss progress Analyze: Evaluate which reaction paths are effective Compare experiments to determine conditions or materials that caused significant change Show relationships of how materials were created and used through the Symyx unique Reaction Relay visualization capability Evaluate multiple pathways with the respective yields to a desired material through Retrosynthetic Analysis visualization
Accelrys Formulations Notebook	An Electronic Laboratory Notebook (ELN) specifically designed to solve the challenges faced by pharmaceutical, chemical, and personal–product formulators. Symyx Formulations Notebook is a recipe editor and analytical data repository that enables scientists to quickly compile formulation data–including composition, manufacturing, and analyses. Simplify information management, Save time Improve data and formulation quality Compile formulation data–including composition, manufacturing, and analyses Facilitate rapid data aggregation for reports, including FDA submissions, by spanning discovery and development with a single Notebook platform. Prepare: Design formulations efficiently Quickly find and reuse existing information using a searchable global database of formulations, analytical data, and other associated information Simplify formulation design and notebook entry using tailored editors specifically designed for formulators using standard units such as % w/w and mg/mL Streamline planning and execution with automatic formulation calculations, and adjust the amount of extra granular excipients based on granulation yield Document: Experiments, batch records, and analytical data Design and record formulations Create batch records automatically Save time and improve information quality with automatic generation of batch records and flow diagrams Ease regulatory burdens with electronic recording of batch records with a 21 CFR Part 11 compliance–enabling system Analyze: Streamline analysis and technology transfer Facilitate data transfer and management with a searchable global data repository Rapidly find formulations, analytical data, and background information Streamline technology transfer with easily accessible documentation for the entire formulation process with consistent electronic batch records
Accelrys Process Notebook	An Electronic Laboratory Notebook (ELN) designed specifically to solve the challenges faced by process chemists, improving information management, saving time, and enhancing experiment quality. Symyx Process Notebook focuses on more efficient route selection, process development/optimization, and process scale–up, resulting in time savings up to 25%: Document Access Share Reuse information Make informed decisions and design better experiments with a searchable global database of corporate knowledge. Prepare: Efficiently Plan Experiments: Simplify experimental setup with document editors designed for process chemists to utilize automated stoichiometric and scaling calculations Enable faster and better process optimization with the ability to plan and execute parallel experiments Document: Record Experiments and Create GMP Documentation: Enable rapid, convenient procedure entry Improve information with quality Customizable QuickText and a built-in database of chemicals and associated properties Save time and streamline the generation of GMP documentation by automatically generating batch records and process flow diagrams Analyze: Rapidly Evaluate Chemical Process Information: Streamline technology transfer across the clinical supply chain and outsourcing partners with standardized and accessible documentation of all chemical process information Provide detailed campaign planning with the multi-step process planner, including the analysis of materials, resources, waste disposal, and overall costs Facilitate rapid data aggregation for reports with a single Notebook platform spanning discovery and development, including FDA submissions
Accelrys Notebook	A single, enterprise electronic laboratory notebook (ELN) that helps scientists quickly and easily record, find, report, and reuse experiments—and share information with colleagues Symyx Notebook is uniquely designed to be used out-of-the-box across multiple scientific disciplines including analytical chemistry, synthesis, and biology, from discovery through manufacturing. Built on a robust, scalable, and secure informatics platform, Symyx Notebook consolidates experimental data, forms data, and text into fully versioned, searchable documents that can be shared over global networks with project team members and contract research organizations. Symyx Notebook is the result of close collaboration with several large pharmaceutical companies and broad experience with discipline-specific notebooks in large, multi-site deployments. Key benefits Enhance workflow productivity Consolidate experimental data Improve collaboration Minimize data errors Simplify regulatory compliance Implement consistent processes across organizations Protect intellectual property (IP) Search within and across experiments Full text and index searching, including searchable image annotations, enable scientists to rapidly locate (and quickly repeat or learn from) previous experiments. Extend or add new capabilities Customize or add new functionality using the Software Developer Kit—or engage Symyx Services to build it for you. Save time, foster collaboration, and improve data accuracy and consistency: A single notebook for regulated and non-regulated environments improves productivity, knowledge sharing, data quality, and process harmonization. Highly configurable templates provide structure to pre-define data inputs and signing requirements—and flexibility for run-time inclusion of new tests Pre-defined data inputs and integration with other laboratory systems improve data consistency and minimize errors A centralized, secure Oracle data repository enables scientists to compare results and leverage others’ knowledge to make better, faster decisions Workflows speed reviews and routing of documents for approval Flexible, easily formatted tables enable scientists to quickly input data using manual data entry, auto-fill data population, or data transfer from integrated hardware Flexible sections, templates, workflows, user roles, and security minimizes IT support and the need for customizations Ensure regulatory compliance, data security, and adherence to Standard Operating Procedures (SOPs): Features supporting work in 21 CFR 11 compliant and Good Practice (GxP) environments include: Audit trail documents of who created or edited notebook entries Authentication of industry-standard products to enforce security Comment track changes when modifications are saved Data security settings that limit access to specified data repositories, users, or groups of users to support specific requirements Electronic signature and countersignature support of Standard Operating Procedures User role and workflow configuration support signatures and reviews Document versioning that allows modifications to be compared Collect data efficiently and minimize errors: Integrate with popular laboratory systems and instruments that include: Spreadsheet, statistical analysis, kinetic modeling, and visualization software and leading scientific data management systems Nearly all modern Mettler-Toledo and Sartorius balances, enabling scientists to retrieve calibration information and record actual amounts directly from balances

Information and documentation system for ALL the different labs

A flexible, enterprise Electronic Laboratory Notebook (ELN) that streamlines the capture of analytical chemistry information and processes, and improves collaboration with colleagues and contract research organizations.