A PASS application is illustrated by the example of prediciting the activity spectrum for LEVAMISOLE (Pa and Pi are the calculated probabilities for presence and absence of each activity). LEVAMISOLE has been launched as antihelmintic in 1969 and as immunomodulator in 1980. The known activities are found in LEVAMISOLE's activity spectrum and even some new activities are predicted. Predicted activity spectrum broadens the potential of the compound. 

PASS Pro - Prediction of Activity Spectra for Substances
   
Copyright
1998-1999 V.V.Poroikov, D.A.Filimonov & Associates
   
Chemical Structure File: levamiso
le.mol

>  <ACTIVITY_PREDICTION>
 
25  Substructure descriptors;  0  new.
 
46  Possible activities.

Pa   Pi     for Activity:
0.848  0.004  Immunostimulant
0.818 0.004  Antihelmintic
0.773 0.004   Anorexic
0.755  0.001 Succinic dehydrogenase inhibitor
0.758   0.007  Spasmogenic
0.744   0.004  Acetylcholine nicotinic agonist
0.694  0.009   Immunomodulator
0.575   0.011 Immunosuppressant
0.566 0.005 Alpha adrenoreceptor agonis
0.539   0.015 Muscle relaxant
0.533  0.014  Skeletal muscle relaxant