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AKos
Consulting & Solutions GmbH
a chemoinformatics company

 

 

AKos Consulting & Solutions Deutschland GmbH
Telephone
+49 7627 970068
Fax
+49 7627 970067
Fax to Mail
+49 1805 744743 8318
E-Mail
General Information:

 

Who benefits: Content:
Every chemist and biologist CWM Global Search - new datasources for version 4.5
Scientist analyzing and working with Proteins New version Proteax 1.3 - protein variants made easy
IT manager AKos GmbH has resources for Oracle programming and for chemoinformatics projects.
Medicinal chemist, modeler, marketing department AKos GmbH signed an agreement with Evolvus Systems for providing the service to generate custom made databases.

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CWM Global Search allows searching the Internet by structure, synonym and CAS Registry Number. In a Quick Search, we return structure, names and CAS Registry Numbers* within seconds. The Global Search allows a comprehensive search and the resulting links are organized by topics. A search by name can automatically invoke another search by structure and/or CAS Registry Number, or any combination of these. CWM Global Search presently searches 50 free chemical and pharma relevant databases  -- containing more than 100 million pages which associate chemical structures with data.

All you have to do is to open the URL http://cwmglobalsearch.com/gsweb in your Internet Explorer or Firefox on Windows, or Safari on Macintosh-->

New datasources in version 4.5 of CWM Global Search:
  • ChemAxon Chemicalize Search (Exact, Substructure and structure  similarity)
    Allows to perform structure searches (including Substructure and Similarity) in Wikipedia

  • ACS Publications (Free text and CAS Numbers)
    Search over more than 35 journals, Chemical & Engineering News, ACS Legacy Archives, and the ACS Symposium Series

  •  Molport (Exact structure  search)
    Find suppliers for more than 7 million compounds

  • Scirus (Free text and CAS Numbers)
    A very comprehensive science-specific search engine on the Internet searching more than 410 million science-specific Web pages.

  • eChemPortal (Free text and CAS Numbers)
    Allows for simultaneous search of multiple databases for Physical chemical properties,  Environmental Fate and Behaviour, Ecotoxicity, Toxicity and GHS Classifications.

  • Google Patents (Free text)
    Allows to search more than 7 million patents and a million patent applications from the USPTO

  • Binding Database (Exact, Substructure and structure  similarity)
    The Binding Database makes experimental data on the non covalent association of molecules in solution searchable via the WWW.  Search for binding data  for more than 270 000 small molecules associated with more than 5000 targets.

  • Protein Data Bank (PDB) (Exact, Substructure and structure  similarity)
    3D structures of large biological molecules, including proteins and nucleic acids associated with small molecule. Search for more than 11 000 small molecules (including standard and modified amino acids/nucleotides, small molecule ligands and solvent molecules) and find more than 65 000 large molecules, proteins and nucleic acids.

At the first time you will be asked to install the Microsoft Silverlight Plug-In, provided it is not already installed. 

We recommend to start by reading the installation notes at cwmglobalsearch.com/installation

A free version is available that is restricted to searches at Google, PubChem, ChemSpider and AKosSamples.

The full version is 240 Euro per user.

We sincerely are interested in your feed-back. Please use the feedback button in the application. 

Some of the new sources in CWM Global Search

Spot the difference - and get it right!
Can you name proteins just by looking at them? Proteax DerNot expressions clearly show you how much two proteins differ. Works with cyclic chains too.

Protein SAR tables - impossible you say ? No, not at all.
Proteax can name your biopharmaceutical candidates so you get consistent and meaningful labels for your protein SAR tables.

Having trouble with your weight ?
Does the analytical department claim a molecule weight of 9243.5 Da but your sequence says 9202 Da ? Let Proteax enable seamless communication between mass-spec and medicinal chemistry.

Can your chemists and bioinformatics people agree ?
Is it a structure ? Is it a sequence ?... Imagine that they used Proteax - a consistent way of representing biopharmaceuticals that lets you see molecules as sequences or structures as you please.

"Can you generate 1000 controlled mutations for me this afternoon ?"
Applied DerNot expressions let you create protein derivatives through simple Excel expressions. With chemically consistent results
.

 

Proteax for Spreadsheets 1.3 released
Proteax for Spreadsheets 1.3 is now ready for download. Improved layout and graphical rendering of chemical structures.

  • The image to the right is an actual rendering of Cyclosporin CsA generated directly from sequence. Unmodified natural amino acids are shown as green "bubbles".
  • Optional name and number residue labels.
  • 64-bit Microsoft Excel 2010 directly supported.
You can get a fully functional trial version of Proteax for Spreadsheets by downloading it here.

 

Proteax Desktop and Proteax Cartridge downloads
With the release of Proteax 1.3 all Proteax products will be available for direct download from the Biochemfusion web site.
  • Proteax Desktop - Use Proteax from .NET, Python, Pascal, or C/C++.
  • Proteax Cartridge - Use Proteax SQL extensions and indexing inside Oracle databases.

Discounted licenses until year-end
There is still time to get a Proteax for Spreadsheets license for only 350,-. This is an introductory offer that expires December 31st.

Can your chemists and bioinformatics people agree ?
Is it a structure ? Is it a sequence ?... Imagine that they used Proteax - a consistent way of representing biopharmaceuticals that lets you see molecules as sequences or structures as you please.

"Can you generate 1000 controlled mutations for me this afternoon ?"
Applied DerNot expressions let you create protein derivatives through simple Excel expressions. With chemically consistent results
.
 

Programming

resources

You only know what you have experienced! Our co-workers have a lot of experience.

  • We sell programs and cooperate with people for building applications. One of us has 18 years Oracle programming experience. His development tools for ORACLE enable us to build applications in days instead of months.

  • Some of us have 20 years experience building chemoinformatics applications in low and high throughput screening, and building and merging structure databases.

  • Others co-workers have experience training commercial and in-house programs.

 

Custom made databases

AKos GmbH works with Evolvus System that offers as service to build custom made databases for chemical and pharmaceutical companies. This can be databases for a few compounds with all available data, or databases for many compounds with customer selected fields. This can be excerpts from patents or a subsets of already collected data to 3.8 million compounds.  

* CAS Registry Number and Synonym CAS Registry Number, SciFinder are registered trademarks of the American Chemical Society (ACS). All Rights Reserved. JDraw is a Java applet structure editor from Accelrys, Inc.

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